This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boivin, G.
Right arrow Articles by Bergeron, M. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boivin, G.
Right arrow Articles by Bergeron, M. G.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, February 1999, p. 377-380, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Human Herpesvirus 8 DNA Load in Leukocytes of Human Immunodeficiency Virus-Infected Subjects: Correlation with the Presence of Kaposi's Sarcoma and Response to Anticytomegalovirus Therapy

Guy Boivin,1,2,* Annie Gaudreau,1 Emil Toma,3 Richard Lalonde,4 Jean-Pierre Routy,4 Gilles Murray,2 Julie Handfield,1 and Michel G. Bergeron1,2

Infectious Disease Research Center of the Centre Hospitalier de l'Université Laval1 and Division of Microbiology,2 Université Laval, Québec City, and Department of Microbiology, Université de Montréal,3 and Department of Medicine, McGill University,4 Montréal, Quebec, Canada

Received 9 March 1998/Returned for modification 18 May 1998/Accepted 31 October 1998

Specific human herpesvirus 8 (HHV-8) DNA sequences were found in leukocytes of 12 of 29 (41.4%) AIDS subjects with Kaposi's sarcoma (KS), whereas they were found in 4 of 43 (9.3%) AIDS subjects without KS (P = 0.003), although the peak HHV-8 DNA load in PCR-positive subjects with KS (mean, 425 copies per 0.2 µg of DNA) did not significantly differ from the one found in PCR-positive patients without KS (mean, 218 copies). The use of intravenous ganciclovir or foscarnet therapy to treat cytomegalovirus disease did not affect the HHV-8 DNA load in seven patients for whom serial samples were analyzed.

* Corresponding author. Mailing address: CHUL, RC-709, 2705 Blvd. Laurier, Sainte-Foy, Québec, Canada G1V 4G2. Phone: (418) 654-2705. Fax: (418) 654-2715. E-mail: Guy.Boivin{at}crchul.ulaval.ca.

Antimicrobial Agents and Chemotherapy, February 1999, p. 377-380, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Martro, E., Cannon, M. J., Dollard, S. C., Spira, T. J., Laney, A. S., Ou, C.-Y., Pellett, P. E. (2004). Evidence for both Lytic Replication and Tightly Regulated Human Herpesvirus 8 Latency in Circulating Mononuclear Cells, with Virus Loads Frequently below Common Thresholds of Detection. J. Virol. 78: 11707-11714 [Abstract] [Full Text]  
  • Sergerie, Y., Abed, Y., Roy, J., Boivin, G. (2004). Comparative Evaluation of Three Serological Methods for Detection of Human Herpesvirus 8-Specific Antibodies in Canadian Allogeneic Stem Cell Transplant Recipients. J. Clin. Microbiol. 42: 2663-2667 [Abstract] [Full Text]  
  • Broccolo, F., Locatelli, G., Sarmati, L., Piergiovanni, S., Veglia, F., Andreoni, M., Butto, S., Ensoli, B., Lusso, P., Malnati, M. S. (2002). Calibrated Real-Time PCR Assay for Quantitation of Human Herpesvirus 8 DNA in Biological Fluids. J. Clin. Microbiol. 40: 4652-4658 [Abstract] [Full Text]  
  • Sarid, R., Klepfish, A., Schattner, A. (2002). Virology, Pathogenetic Mechanisms, and Associated Diseases of Kaposi Sarcoma-Associated Herpesvirus (Human Herpesvirus 8). Mayo Clin Proc. 77: 941-949 [Abstract]  
  • White, I. E., Campbell, T. B. (2000). Quantitation of Cell-Free and Cell-Associated Kaposi's Sarcoma-Associated Herpesvirus DNA by Real-Time PCR. J. Clin. Microbiol. 38: 1992-1995 [Abstract] [Full Text]  
  • Lallemand, F., Desire, N., Rozenbaum, W., Nicolas, J.-C., Marechal, V. (2000). Quantitative Analysis of Human Herpesvirus 8 Viral Load Using a Real-Time PCR Assay. J. Clin. Microbiol. 38: 1404-1408 [Abstract] [Full Text]  
  • Gustafson, E. A., Schinazi, R. F., Fingeroth, J. D. (2000). Human Herpesvirus 8 Open Reading Frame 21 Is a Thymidine and Thymidylate Kinase of Narrow Substrate Specificity That Efficiently Phosphorylates Zidovudine but Not Ganciclovir. J. Virol. 74: 684-692 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»