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Antimicrobial Agents and Chemotherapy, February 1999, p. 385-389, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Haemophilus influenzae and Moraxella
catarrhalis from Patients with Community-Acquired Respiratory
Tract Infections: Antimicrobial Susceptibility Patterns from the SENTRY
Antimicrobial Surveillance Program (United States and
Canada, 1997)
Gary V.
Doern,*
Ronald N.
Jones,
Michael A.
Pfaller,
Kari
Kugler, and
The Sentry Participants Group
Medical Microbiology Division, Department of
Pathology, University of Iowa College of Medicine, Iowa City, Iowa
Received 13 April 1998/Returned for modification 28 July
1998/Accepted 31 October 1998
Between February and June of 1997, a large number of
community-acquired respiratory tract isolates of Haemophilus
influenzae (n = 1,077) and Moraxella
catarrhalis (n = 503) from 27 U.S. and 7 Canadian medical centers were characterized as part of the SENTRY Antimicrobial Surveillance Program. Overall prevalences of
-lactamase production were 33.5% in H. influenzae and
92.2% in M. catarrhalis with no differences noted
between isolates recovered in the United States and those from Canada.
Among a total of 21 different antimicrobial agents tested,
including six cephalosporins, a
-lactamase inhibitor combination,
three macrolides, tetracycline, trimethoprim-sulfamethoxazole (TMP-SMX), rifampin, chloramphenicol, five fluoroquinolones, and quinupristin-dalfopristin, resistance rates of >5% with H. influenzae were observed only with cefaclor (12.8%) and TMP-SMX
(16.2%).
*
Corresponding author. Mailing address: Department
of Pathology, C606 GH, University of Iowa College of Medicine, Iowa
City, IA 52242. Phone: (319) 356-8616. Fax: (319) 356-4916. E-mail: gary-doern{at}uiowa.edu.
Antimicrobial Agents and Chemotherapy, February 1999, p. 385-389, Vol. 43, No. 2
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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