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Antimicrobial Agents and Chemotherapy, March 1999, p. 678-680, Vol. 43, No. 3
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Influence of Renal Failure on Intestinal Clearance of Ciprofloxacin in Rats

Sophie Dautrey,1,2 Lydia Rabbaa,3 Denise Laouari,4 Bernard Lacour,3 Claude Carbon,1 and Robert Farinotti2,3,*

CRI no. 4 U 002D,1 Service de Pharmacie Clinique et des Biomatériaux,2 and INSERM U 426,4 G. H. Bichat-C. Bernard, 75018 Paris, and Laboratoire de Pharmacie Clinique, Faculté de Pharmacie de Paris XI, 92290 Chatenay Malabry,3 France

Received 3 June 1998/Returned for modification 5 September 1998/Accepted 7 December 1998

Following intravenous doses, ciprofloxacin pharmacokinetics in control and nephrectomized rats were studied. There were no differences between control and nephrectomized rats for area under the concentration-time curve in plasma or biliary clearance. The intestinal clearance of ciprofloxacin was increased in nephrectomized rats. Intestinal elimination seems to compensate partially for the decrease in urinary excretion of ciprofloxacin in nephrectomized rats.

* Corresponding author. Mailing address: Service de Pharmacie Clinique et des Biomatériaux, G. H. Bichat-C. Bernard, 46, rue Henri Huchard, 75018 Paris, France. Phone: 33-1-40-25-80-05. Fax: 33-1-42-63-58-25. E-mail: robert.farinotti{at}bch.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, March 1999, p. 678-680, Vol. 43, No. 3
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Pea, F., Poz, D., Viale, P., Pavan, F., Furlanut, M. (2006). Which reliable pharmacodynamic breakpoint should be advised for ciprofloxacin monotherapy in the hospital setting? A TDM-based retrospective perspective. J Antimicrob Chemother 58: 380-386 [Abstract] [Full Text]  


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