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Antimicrobial Agents and Chemotherapy, March 1999, p. 681-682, Vol. 43, No. 3
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Penetration of Meropenem in Lung, Bronchial Mucosa, and Pleural Tissues

Baudouin Byl,1,* Frédérique Jacobs,1 Ingrid Roucloux,1 Philippe de Franquen,2 Matteo Cappello,2 and Jean-Pierre Thys1

Infectious Diseases Clinic1 and Thoracic Surgery Department,2 Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium

Received 25 February 1998/Returned for modification 12 July 1998/Accepted 8 December 1998

Lung, bronchial mucosa, and pleural tissue samples were obtained from 14 patients undergoing lung surgery 1 to 5 h after administration of 1 g of meropenem. The mean (range) peak concentrations of meropenem were 3.9 (0.2 to 8.2), 6.6 (3.0 to 13.3), and 2.8 (0.6 to 7.8) mg/kg of tissue, respectively, exceeding the MICs at which 90% of isolates are inhibited for most respiratory pathogens.

* Corresponding author. Mailing address: Infectious Diseases Clinic, Erasme Hospital, Route de Lennik 808, B-1070 Brussels, Belgium. Phone: 32 2 5556746. Fax: 32 2 5553912. E-mail: baudouin.byl{at}ulb.ac.be.

Antimicrobial Agents and Chemotherapy, March 1999, p. 681-682, Vol. 43, No. 3
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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