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Antimicrobial Agents and Chemotherapy, March 1999, p. 690-692, Vol. 43, No. 3
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Declining Concentrations of Dihydroartemisinin in Plasma during 5-Day Oral Treatment with Artesunate for Falciparum Malaria

Nguyen Xuan Khanh,1 Peter J. de Vries,2,* Le Dang Ha,1 Chris J. van Boxtel,3 Richard Koopmans,3 and Piet A. Kager2

Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Hanoi, Vietnam,1 and Department of Clinical Pharmacology and Pharmacotherapy3 and Department of Infectious Diseases, Tropical Medicine and AIDS,2 Academic Medical Center, University of Amsterdam

Received 27 February 1998/Returned for modification 14 September 1998/Accepted 27 December 1998

Six patients with uncomplicated falciparum malaria received artesunate for 5 days. Plasma concentrations of artesunate and dihydroartemisinin were determined by high-performance liquid chromatography with electrochemical detection. The concentrations of dihydroartemisinin in plasma 2 h after a dose showed a time-dependent decline. Concentrations of artesunate in plasma especially after the last dose, were very low. Despite this, all patients responded with a fast recovery.

* Corresponding author. Mailing address: Academic Medical Center F4-221, Department of Infectious Diseases, Tropical Medicine & AIDS, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands. Phone: 31-20-5664380. Fax: 31-20-6972286. E-mail: P.J.deVries{at}amc.uva.nl.

Antimicrobial Agents and Chemotherapy, March 1999, p. 690-692, Vol. 43, No. 3
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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