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Antimicrobial Agents and Chemotherapy, March 1999, p. 702-704, Vol. 43, No. 3
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Amphotericin B- and Fluconazole-Resistant Candida spp., Aspergillus fumigatus, and Other Newly Emerging Pathogenic Fungi Are Susceptible to Basic Antifungal Peptides

Eva J. Helmerhorst,1,* Ingrid M. Reijnders,1 Wim van 't Hof,1 Ina Simoons-Smit,2 Enno C. I. Veerman,1 and Arie V. Nieuw Amerongen1

Academic Centre for Dentistry (ACTA), Department of Oral Biochemistry, Vrije Universiteit,1 and Department of Clinical Microbiology, Academic Hospital Vrije Universiteit (AZVU),2 Amsterdam, The Netherlands

Received 20 August 1998/Returned for modification 3 November 1998/Accepted 17 December 1998

The present study shows that a number of basic antifungal peptides, including human salivary histatin 5, a designed histatin analog designated dhvar4, and a peptide from frog skin, PGLa, are active against amphotericin B-resistant Candida albicans, Candida krusei, and Aspergillus fumigatus strains and against a fluconazole-resistant Candida glabrata isolate.

* Corresponding author. Mailing address: ACTA, Department of Oral Biochemistry, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. Phone: 3120-4448674. Fax: 3120-4448685. E-mail: EJ.Helmerhorst.obc.acta{at}med.vu.nl.

Antimicrobial Agents and Chemotherapy, March 1999, p. 702-704, Vol. 43, No. 3
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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