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Antimicrobial Agents and Chemotherapy, April 1999, p. 947-949, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Alterations in GyrA and ParC Associated with Fluoroquinolone Resistance in Enterococcus faecium

Nagwa el Amin, Shah Jalal, and Bengt Wretlind*

Division of Clinical and Oral Bacteriology, Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Huddinge University Hospital, S-14186 Huddinge, Sweden

Received 5 October 1998/Returned for modification 10 November 1998/Accepted 28 January 1999

High-level quinolone resistance in Enterococcus faecium was associated with mutations in both gyrA and parC genes in 10 of 11 resistant strains. One low-level resistant strain without such mutations may instead possess an efflux mechanism or alterations in the other subunits of the gyrase or topoisomerase IV genes. These findings are similar to those for other gram-positive bacteria, such as Enterococcus faecalis.

* Corresponding author. Mailing address: Division of Clinical and Oral Bacteriology, Huddinge Hospital F82, S-14186 Huddinge, Sweden. Phone: 46-8-5858 7841. Fax: 46-8-711 3918. E-mail: bengt.wretlind{at}impi.ki.se.

Antimicrobial Agents and Chemotherapy, April 1999, p. 947-949, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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