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Antimicrobial Agents and Chemotherapy, April 1999, p. 963-965, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Trovafloxacin in Combination with Vancomycin against Penicillin-Resistant Pneumococci in the Rabbit Meningitis Model

Dina Rodoni,1 Fränzi Hänni,1 Cynthia M. Gerber,2 Marianne Cottagnoud,2 Klaus Neftel,2 Martin G. Täuber,3 and Philippe Cottagnoud1,*

Department of Internal Medicine, Inselspital,1 Department of Internal Medicine, Zieglerspital,2 and Institute for Medical Microbiology, University of Berne,3 Berne, Switzerland

Received 8 July 1998/Returned for modification 8 September 1998/Accepted 30 January 1999

Trovafloxacin, a new fluoroquinolone, produced bactericidal activity (-0.33 ± 0.13 Delta log10 CFU/ml · h; intravenously [i.v.] administered dose, 15 mg/kg) comparable to that of vancomycin (-0.39 ± 0.18 Delta log10 CFU/ml · h; i.v. administered dose, 20 mg/kg) in the treatment of experimental meningitis in rabbits due to a pneumococcal strain highly resistant to penicillin (MIC of penicillin G, 4 µg/ml). The combination of both drugs significantly increased (P < 0.05) the killing rate (-0.60 ± 0.23 Delta log10 CFU/ml · h) compared to that produced by either monotherapy. These results were also confirmed in vitro.

* Corresponding author. Mailing address: Department of Internal Medicine, Inselspital, Freiburgstrasse, 3010 Berne, Switzerland. Phone: 41316322111. Fax: 41316323847. E-mail: pcottagn{at}insel.ch.

Antimicrobial Agents and Chemotherapy, April 1999, p. 963-965, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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