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Antimicrobial Agents and Chemotherapy, April 1999, p. 975-977, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Potentiation of Isoniazid Activity against Mycobacterium tuberculosis by Melatonin

Ian Wiid,1 Eileen Hoal-van Helden,1 Dinie Hon,1 Carl Lombard,2 and Paul van Helden1,*

MRC Centre For Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch Medical School,1 and Centre for Epidemiological Research in South Africa, MRC,2 Tygerberg 7505, South Africa

Received 3 June 1998/Returned for modification 26 August 1998/Accepted 28 January 1999

The limited number of effective antituberculosis drugs available necessitates optimizing current treatments. We show that melatonin, which is synthesized in the pineal gland, can cause at least a threefold increase in the efficacy of isoniazid. This suggests that tuberculosis chemotherapy can be improved by innate molecules such as melatonin.

* Corresponding author. Mailing address: MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, Faculty of Medicine, University of Stellenbosch, P.O. Box 19063, Tygerberg 7505, South Africa. Phone: 27-21-9389401, ext. 124. Fax: 27-21- 9317810. E-mail: pvh{at}gerga.sun.ac.za.

Antimicrobial Agents and Chemotherapy, April 1999, p. 975-977, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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  • De Logu, A., Onnis, V., Saddi, B., Congiu, C., Schivo, M. L., Cocco, M. T. (2002). Activity of a new class of isonicotinoylhydrazones used alone and in combination with isoniazid, rifampicin, ethambutol, para-aminosalicylic acid and clofazimine against Mycobacterium tuberculosis. J Antimicrob Chemother 49: 275-282 [Abstract] [Full Text]  


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