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Antimicrobial Agents and Chemotherapy, April 1999, p. 985-987, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Anti-Influenza Virus Drug Rimantadine Has Trypanocidal Activity

John M. Kelly,1,* Michael A. Miles,1 and Anita C. Skinner2,dagger

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT,1 and Division of Virology, National Institute for Medical Research, The Ridgeway, London NW7 1AA,2 United Kingdom

Received 24 November 1998/Accepted 27 January 1999

We report here that bloodstream forms of the African trypanosome, Trypanosoma brucei, are sensitive to the anti-influenza virus drug rimantadine (50% inhibitory concentration of 1.26 µg ml-1 at pH 7.4). The activity is pH dependent and is consistent with a mechanism involving inhibition of the ability to regulate internal pH. Rimantadine is also toxic to the trypanosomatid parasites Trypanosoma cruzi and Leishmania major.

* Corresponding author. Mailing address: Department of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St., London WC1E 7HT, United Kingdom. Phone: 44 171 927 2330. Fax: 44 171 636 8739. E-mail: j.m.kelly{at}lshtm.ac.uk.

dagger Present address: Eastman Dental Institute, University College London, London WC1X 8LD, United Kingdom.

Antimicrobial Agents and Chemotherapy, April 1999, p. 985-987, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Kelly, J. M., Quack, G., Miles, M. M. (2001). In Vitro and In Vivo Activities of Aminoadamantane and Aminoalkylcyclohexane Derivatives against Trypanosoma brucei. Antimicrob. Agents Chemother. 45: 1360-1366 [Abstract] [Full Text]  


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