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Antimicrobial Agents and Chemotherapy, April 1999, p. 988-989, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Inhibition of the Emergence of Ciprofloxacin Resistance in Streptococcus pneumoniae by the Multidrug Efflux Inhibitor Reserpine

Penelope N. Markham*

Influx, Inc., Chicago Technology Park, Chicago, Illinois 60612

Received 1 September 1998/Returned for modification 20 October 1998/Accepted 13 January 1999

Recent evidence supports the contribution of a multidrug efflux mechanism to fluoroquinolone resistance in Streptococcus pneumoniae. In this paper I show that reserpine, an inhibitor of multidrug transporters in gram-positive bacteria, dramatically suppresses the in vitro emergence of ciprofloxacin-resistant variants of S. pneumoniae, suggesting that the combination of a fluoroquinolone with an inhibitor of multidrug transport may help preserve the efficacy of this class of antibiotics.

* Mailing address: Influx, Inc., Chicago Technology Park, Suite 116, 2201 West Campbell Park Dr., Chicago, IL 60612. Phone: (312) 492-7760. Fax: (312) 413-9303. E-mail: pmarkham{at}uic.edu.

Antimicrobial Agents and Chemotherapy, April 1999, p. 988-989, Vol. 43, No. 4
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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