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Antimicrobial Agents and Chemotherapy, May 1999, p. 1256-1257, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

In Vitro and In Vivo Experimental Activities of Antifungal Agents against Fusarium solani

J. Guarro,1,* I. Pujol,2 and E. Mayayo3

Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili,1 and Laboratori de Microbiologia, Hospital Universitari de Sant Joan de Reus,2 43201 Reus, and Servei de Patologia, Hospital Universitari de Tarragona Joan XXIII, Tarragona,3 Tarragona, Spain

Received 28 September 1998/Returned for modification 21 December 1998/Accepted 11 February 1999

In the treatment of disseminated Fusarium infections, amphotericin B either alone or in combination with flucytosine and rifampin is the drug therapy most frequently used. The efficacy of these antifungal drugs was evaluated in a murine disseminated-infection model, with five strains of Fusarium solani. All the treatments were clearly ineffective.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201 Reus, Tarragona, Spain. Phone: 977-759359. Fax: 977-759322. E-mail: umb{at}astor.urv.es.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1256-1257, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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