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Antimicrobial Agents and Chemotherapy, May 1999, p. 1264-1266, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Comparison of In Vitro Activity of Liposomal Nystatin against Aspergillus Species with Those of Nystatin, Amphotericin B (AB) Deoxycholate, AB Colloidal Dispersion, Liposomal AB, AB Lipid Complex, and Itraconazole

Karen L. Oakley,1 Caroline B. Moore,2 and David W. Denning1,3,4,*

Departments of Medicine1 and Microbiology,2 Hope Hospital, Salford, and University of Manchester,3 and Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital,4 Manchester M8 6RB, United Kingdom

Received 21 August 1998/Returned for modification 13 October 1998/Accepted 1 March 1999

We compared the in vitro activity of liposomal nystatin (Nyotran) with those of other antifungal agents against 60 Aspergillus isolates. Twelve isolates were itraconazole resistant. For all isolates, geometric mean (GM) MICs (micrograms per milliliter) were 2.30 for liposomal nystatin, 0.58 for itraconazole, 0.86 for amphotericin B (AB) deoxycholate, 9.51 for nystatin, 2.07 for liposomal AB, 2.57 for AB lipid complex, and 0.86 for AB colloidal dispersion. Aspergillus terreus (GM, 8.72 µg/ml; range, 8 to 16 µg/ml) was significantly less susceptible to all of the polyene drugs than all other species (P = 0.0001).

* Corresponding author. Mailing address: Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Delaunays Road, Manchester M8 6RB, United Kingdom. Phone: 0161 720 2734. Fax: 0161 720 2732. E-mail: ddenning{at}fs1.ho.man.ac.uk.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1264-1266, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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