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Antimicrobial Agents and Chemotherapy, May 1999, p. 1270-1273, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

beta -Lactamase Production and Antimicrobial Susceptibility of Oral Heterogeneous Fusobacterium nucleatum Populations in Young Children

E. Könönen,1,2,* A. Kanervo,1 K. Salminen,3 and H. Jousimies-Somer1

Anaerobe Reference Laboratory, National Public Health Institute, Helsinki,1 and Pfizer Finland, Espoo,3 Finland, and Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark2

Received 4 August 1998/Returned for modification 23 November 1998/Accepted 12 February 1999

Oral Fusobacterium nucleatum populations from 20 young, healthy children were examined for beta -lactamase production. Ten children (50%) harbored, altogether, 25 beta -lactamase-positive F. nucleatum isolates that were identified as F. nucleatum subsp. polymorphum, F. nucleatum subsp. nucleatum, and F. nucleatum subsp. vincentii (J. L. Dzink, M. T. Sheenan, and S. S. Socransky, Int. J. Syst. Bacteriol. 40:74-78, 1990). In vitro susceptibility of these beta -lactamase-producing and 26 non-beta -lactamase-producing F. nucleatum isolates was tested with penicillin G, amoxicillin-clavulanic acid, tetracycline hydrochloride, metronidazole, trovafloxacin, and azithromycin. Except for penicillin G, the antimicrobials exhibited good activity against all F. nucleatum isolates.

* Corresponding author. Mailing address: Anaerobe Reference Laboratory, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. Phone: 358-9-47448248. Fax: 358-9-47448238. E-mail: Eija.Kononen{at}ktl.fi.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1270-1273, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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