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Antimicrobial Agents and Chemotherapy, May 1999, p. 1277-1280, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Pharmacokinetics of a Clarithromycin Suspension Administered via Nasogastric Tube to Seriously Ill Patients

Douglas N. Fish1,* and Edward Abraham2

Department of Pharmacy Practice, School of Pharmacy,1 and Division of Pulmonary Sciences and Critical Care Medicine, School of Medicine,2 University of Colorado Health Sciences Center, Denver, Colorado

Received 10 August 1998/Returned for modification 8 December 1998/Accepted 21 February 1999

The pharmacokinetics of clarithromycin and its 14-(R)-hydroxylated metabolite were studied on two separate occasions after nasogastric administration of 500 mg of a clarithromycin suspension to 16 seriously ill adults in an intensive care unit. The clarithromycin suspension appeared to be adequately absorbed, and the pharmacokinetics of neither clarithromycin nor 14-(R)-hydroxyclarithromycin differed significantly between the two dosing periods. No substantial differences in pharmacokinetics were observed compared to previously published studies of other adult populations. Minimal intrapatient variability of pharmacokinetic parameters was observed in these seriously ill patients.

* Corresponding author. Mailing address: University of Colorado Health Sciences Center, Department of Pharmacy Practice, School of Pharmacy, Campus Box C-238, 4200 East Ninth Ave., Denver, CO 80262. Phone: (303) 315-5136. Fax: (303) 315-4630. E-mail: doug.fish{at}uchsc.edu.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1277-1280, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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