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Antimicrobial Agents and Chemotherapy, May 1999, p. 1291-1293, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Antimicrobial Activities and Postantibiotic Effects of Clarithromycin, 14-Hydroxy-Clarithromycin, and Azithromycin in Epithelial Cell Lining Fluid against Clinical Isolates of Haemophilus influenzae and Streptococcus pneumoniae

Kimberly L. Bergman,1 Keith M. Olsen,1 Tom E. Peddicord,1,dagger Paul D. Fey,2 and Mark E. Rupp2,*

Departments of Pharmacy Practice1 and Internal Medicine,2 University of Nebraska Medical Center, Omaha, Nebraska 68198

Received 4 May 1998/Returned for modification 27 October 1998/Accepted 19 February 1999

The antimicrobial activity of concentrations of selected macrolides found in epithelial cell lining fluid was investigated. Clarithromycin demonstrated greater potency and a significantly longer postantibiotic effect (PAE) than azithromycin against Streptococcus pneumoniae. Azithromycin displayed greater potency, faster killing, and a longer PAE than clarithromycin against Haemophilus influenzae. Drug concentrations in epithelial cell lining fluid similar to those found in tissue did not improve the synergistic potential of 14-hydroxy-clarithromycin and indicate that a maximal PAE may exist despite increasing concentrations of drug.

* Corresponding author. Mailing address: 984031 Nebraska Medical Center, Omaha, NE 68198-4031. Phone: (402) 559-8650. Fax: (402) 559-8300. E-mail: merupp{at}.unmc.edu.

dagger Present address: Department of Pharmacy Practice, Kansas University Medical Center, Kansas City, KS 66160-7231.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1291-1293, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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