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Antimicrobial Agents and Chemotherapy, May 1999, p. 1298-1300, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

In Vitro Activities of Antibiotics Alone and in Combination against Brucella melitensis at Neutral and Acidic pHs

Murat Akova,* Deniz Gür,dagger David M. Livermore,Dagger Tanil Kocagöz,§ and H. Erdal Akalinparallel

Department of Medicine, Section of Infectious Diseases, Hacettepe University School of Medicine, 06100 Ankara, Turkey

Received 17 September 1998/Returned for modification 7 January 1999/Accepted 20 February 1999

Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.

* Corresponding author. Mailing address: Department of Medicine, Section of Infectious Diseases, Hacettepe University School of Medicine, Ankara 06100, Turkey. Phone: 90-312-311 1271. Fax: 90-312-310 4179. E-mail: ma08-k{at}tr-net.net.tr.

dagger Present address: Department of Pediatrics, Clinical Microbiology Laboratory, Hacettepe University School of Medicine, Ankara, Turkey.

Dagger Present address: Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, Colindale, London NW9 5HT, United Kingdom.

§ Present address: Department of Microbiology and Clinical Microbiology, Hacettepe University School of Medicine, Ankara, Turkey.

parallel Present address: Pfizer Ilaçlari A.Ş., Ortaköy 80840, Istanbul, Turkey.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1298-1300, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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