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Antimicrobial Agents and Chemotherapy, May 1999, p. 1304-1306, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Synergistic In Vitro Antimalarial Activity of Omeprazole and Quinine

T. Skinner-Adams* and T. M. E. Davis

Department of Medicine, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia 6160, Australia

Received 18 November 1998/Returned for modification 4 January 1999/Accepted 8 March 1999

Previous studies have shown that the proton pump inhibitor omeprazole has antimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine combinations were synergistic; however, chloroquine and omeprazole combinations were antagonistic. Artemisinin drugs had additive antimalarial activities with omeprazole.

* Corresponding author. Mailing address: University of Western Australia, Department of Medicine, Fremantle Hospital, P.O. Box 480, Fremantle, Western Australia 6160, Australia. Phone: 9431 2523. Fax: 9431 2977. E-mail: tskinner{at}cyllene.uwa.edu.au.

Antimicrobial Agents and Chemotherapy, May 1999, p. 1304-1306, Vol. 43, No. 5
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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