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Antimicrobial Agents and Chemotherapy, June 1999, p. 1347-1349, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Antimicrobial Activities of Amine- and Guanidine-Functionalized Cholic Acid Derivatives

Chunhong Li,1 Matthew R. Lewis,2 Amy B. Gilbert,2 Mark D. Noel,2 David H. Scoville,2 Glenn W. Allman,2 and Paul B. Savage1,*

Department of Chemistry and Biochemistry1 and Department of Microbiology,2 Brigham Young University, Provo, Utah

Received 30 November 1998/Returned for modification 22 January 1999/Accepted 17 March 1999

Compounds in a series of cholic acid derivatives, designed to mimic the activities of polymyxin B and its derivatives, act as both potent antibiotics and effective permeabilizers of the outer membranes of gram-negative bacteria. Some of these compounds rival polymyxin B in antibacterial activity against gram-negative bacteria and are also very active against gram-positive organisms. Other compounds interact synergistically with hydrophobic antibiotics to inhibit bacterial growth.

* Corresponding author. Mailing address: Department of Chemistry and Biochemistry, C100 Benson Science Building, Brigham Young University, Provo, UT 84602. Phone: (801) 378-4020. Fax: (801) 378-5474. E-mail: paul_savage{at}byu.edu.

Antimicrobial Agents and Chemotherapy, June 1999, p. 1347-1349, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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