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Antimicrobial Agents and Chemotherapy, June 1999, p. 1480-1483, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Emergence in France of Multiple Clones of Clinical Streptococcus pneumoniae Isolates with High-Level Resistance to Amoxicillin

Catherine Doit,1 Chawki Loukil,1 Frederic Fitoussi,1 Pierre Geslin,2 and Edouard Bingen1,*

Laboratoire de Microbiologie, Hôpital Robert Debré, 75019 Paris,1 and Centre National de Référence du Pneumocoque, Centre Hospitalier de Créteil, 94010 Créteil,2 France

Received 30 November 1998/Returned for modification 2 February 1999/Accepted 17 March 1999

The genetic relatedness of French isolates of Streptococcus pneumoniae highly resistant to amoxicillin (MIC, >= 4 µg/ml, equal to or exceeding those of penicillin) was investigated by molecular fingerprinting. The results suggest that high-level resistance to amoxicillin has emerged within preexisting penicillin-resistant clones.

* Corresponding author. Mailing address: Service de Microbiologie, Hôpital R. Debré, 48 Bd. Sérurier, 75019 Paris, France. Phone: 33 (1) 40 03 23 40. Fax: 33 (1) 40 03 24 50. E-mail: edouard.bingen{at}rdb.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, June 1999, p. 1480-1483, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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