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Antimicrobial Agents and Chemotherapy, June 1999, p. 1494-1496, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Effect of HSR-903, a New Fluoroquinolone, on the Concentration of Theophylline in Serum

Yoshihito Niki,1,* Shinsuke Watanabe,1 Sadao Tamada,1 Koichiro Yoshida,1 Naoyuki Miyashita,1 Masamitu Nakajima,1 Toshiharu Matsushima,1 Hisayuki Sekino,2 and Osamu Matsuoka2

Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192,1 and Sekino Hospital, 3-28-3, Ikebukuro, Toshima-ku, Tokyo 171-0014,2 Japan

Received 23 June 1998/Returned for modification 16 December 1998/Accepted 12 March 1999

The effect of HSR-903, a new fluoroquinolone, on the concentration of theophylline in serum in healthy male volunteers was investigated. The concentration of theophylline in serum and the urinary excretion rates of theophylline on day 5 of concomitant dosing with HSR-903 tended to increase compared to those on day 4, when theophylline was given alone; however, the urinary excretion rates of 1-methyluric acid and 3-methylxanthine on day 5 of concomitant dosing with HSR-903 tended to decrease in comparison to those on day 4, when theophylline was given alone.

* Corresponding author. Mailing address: Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan. Phone: 81-86-462-1111. Fax: 81-86-463-6510. E-mail: resp{at}med.kawasaki-m.ac.jp.

Antimicrobial Agents and Chemotherapy, June 1999, p. 1494-1496, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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