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Antimicrobial Agents and Chemotherapy, June 1999, p. 1503-1504, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Pharmacokinetics and Pharmacodynamics of Amoxicillin-Sulbactam, a Novel Aminopenicillin-beta -Lactamase Inhibitor Combination, against Escherichia coli

Carlos Bantar,1,* Federico Nicola,1 Hector J. Arenoso,2 Marcelo Galas,3 Liliana Soria,4 Diego Dana,5 Alicia Rossi,3 Hebe Bianchini,1 and Abel Jasovich4

Centro de Educación Médica e Investigaciones Clínicas,1 Laboratorios Bagó S.A.,2 Instituto Nacional de Microbiología "Carlos Malbrán",3 Hospital Privado Antártida,4 and Centro de Farmacología Clínica Aplicada,5 Buenos Aires, Argentina

Received 2 March 1998/Returned for modification 12 August 1998/Accepted 14 March 1999

We evaluated the pharmacokinetics of amoxicillin-sulbactam (AMX-SUL), a novel drug combination, and its pharmacodynamics against Escherichia coli in 12 volunteers receiving a single oral dose (1,000 mg). Peak serum bactericidal and urine inhibitory activities in most volunteers were observed against E. coli strains for which AMX-SUL MICs were low (2- to 4-mg/liter) (2 strains) and high (>= 16-mg/liter) (47 strains), respectively.

* Corresponding author. Mailing address: Laboratorio de Bacteriología, Billinghurst 2447, Buenos Aires (1425), Argentina. Fax: (5411) 4805-3233. E-mail: bantar{at}drwebsa.com.ar.

Antimicrobial Agents and Chemotherapy, June 1999, p. 1503-1504, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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