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Antimicrobial Agents and Chemotherapy, June 1999, p. 1505-1507, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Molecular Characterization of Multidrug Resistance in Streptococcus mitis

Susan M. Poutanen,1,2 Joyce de Azavedo,1,3 Barbara M. Willey,1 Donald E. Low,1,2,3 and Kelly S. MacDonald1,2,*

Department of Microbiology, Mount Sinai and Princess Margaret Hospitals,1 and Department of Medicine2 and Department of Laboratory Medicine and Pathobiology,3 University of Toronto, Toronto, Ontario, Canada

Received 14 September 1998/Returned for modification 27 January 1999/Accepted 21 March 1999

Antimicrobial resistance was characterized for 14 strains of Streptococcus mitis. HinfI restriction fragment length mapping of gyrA PCR amplicons from three ciprofloxacin-resistant isolates correlated with mutations associated with such resistance in other organisms. By using PCR, seven erythromycin-resistant strains were found to possess either the mef or ermB gene. Hybridization revealed tet(M) in seven tetracycline-resistant isolates.

* Corresponding author. Mailing address: Department of Microbiology, Mount Sinai Hospital, 600 University Ave., Room 1484, Toronto, Ontario, Canada M5G 1X5. Phone: (416) 586-8879. Fax: (416) 586-8746. E-mail: kmacdonald{at}mtsinai.on.ca.

Antimicrobial Agents and Chemotherapy, June 1999, p. 1505-1507, Vol. 43, No. 6
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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