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Antimicrobial Agents and Chemotherapy, July 1999, p. 1769-1772, Vol. 43, No. 7
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Activation of the 2'-N-Acetyltransferase Gene [aac(2')-Ia] in Providencia stuartii by an Interaction of AarP with the Promoter Region

David R. Macinga,2 Michael R. Paradise,1 Milica M. Parojcic,1 and Philip N. Rather1,2,*

Research Service, Veterans Affairs Medical Center,1 and Departments of Medicine and of Molecular Biology and Microbiology,2 Case Western Reserve University School of Medicine, Cleveland, Ohio 44106

Received 4 January 1999/Returned for modification 23 March 1999/Accepted 7 May 1999

The aac(2')-Ia gene in Providencia stuartii encodes a 2'-N-acetyltransferase capable of acetylating both peptidoglycan and certain aminoglycoside antibiotics. Regulation of the aac(2')-Ia gene is influenced in a positive manner by the product of the aarP gene, which encodes a small transcriptional activator of the AraC (XylS) family. In this study, we demonstrate the sequence requirements at the aac(2')-Ia promoter for AarP binding and activation.

* Corresponding author. Mailing address: Division of Infectious Diseases BRB-10, Case Western Reserve University, 10900 Euclid Ave., Cleveland, Ohio 44106. Phone: (216) 368-0733. Fax: (216) 368-2034. E-mail: pxr17{at}po.cwru.edu.

Antimicrobial Agents and Chemotherapy, July 1999, p. 1769-1772, Vol. 43, No. 7
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Vakulenko, S. B., Mobashery, S. (2003). Versatility of Aminoglycosides and Prospects for Their Future. Clin. Microbiol. Rev. 16: 430-450 [Abstract] [Full Text]  


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