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Antimicrobial Agents and Chemotherapy, August 1999, p. 2046-2050, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Hydroxyurea Enhances the Activities of Didanosine, 9-[2-(Phosphonylmethoxy)ethyl]adenine, and 9-[2-(Phosphonylmethoxy)propyl]adenine against Drug-Susceptible and Drug-Resistant Human Immunodeficiency Virus Isolates

Sarah Palmer,* Robert W. Shafer, and Thomas C. Merigan

Center for AIDS Research at Stanford, Stanford University Medical Center, Stanford, California 94305-5107

Received 30 October 1998/Returned for modification 8 March 1999/Accepted 13 May 1999

We assessed the effects of hydroxyurea (HU) at a concentration of 50 µM on the in vitro activities of 2',3'-dideoxyinosine (ddI), 9-[2-(phosphonylmethoxy)ethyl]adenine (PMEA), and 9-[2-(phosphonylmethoxy)propyl]adenine (PMPA) against a wild-type human immunodeficiency virus (HIV) type 1 (HIV-1) laboratory isolate and a panel of five well-characterized drug-resistant HIV isolates. Fifty micromolar HU significantly increased the activities of ddI, PMEA, and PMPA against both the wild-type and the drug-resistant HIV-1 isolates. In fixed combinations, both ddI and PMEA were synergistic with HU against wild-type and drug-resistant viruses.

* Corresponding author. Present address: Southern Research Institute/Serquest, Department of Infectious Disease Research, 431 Aviation Way, Frederick, MD 21701-4756. Phone: (301) 694-3232. Fax: (301) 694-7223. E-mail: palmer{at}SRI.org.

Antimicrobial Agents and Chemotherapy, August 1999, p. 2046-2050, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.