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Antimicrobial Agents and Chemotherapy, August 1999, p. 2074-2076, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Stability of Antibiotics Used for Antibiotic-Lock Treatment of Infections of Implantable Venous Devices (Ports)

Thiele Umali Anthony and Lorry G. Rubin*

Division of Infectious Diseases, Department of Pediatrics, Schneider Children's Hospital of Long Island Jewish Medical Center, the Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040

Received 6 November 1998/Returned for modification 22 April 1999/Accepted 3 June 1999

Antibiotic-lock is a treatment for catheter-related bloodstream infections in which a solution containing heparin and an antibiotic dwells in the lumen of the catheter or port. We tested the stability of vancomycin, cefazolin, ticarcillin-clavulanic acid, ceftazidime, or ciprofloxacin combined with heparin after incubation in vitro at 25 or 37°C for intervals of up to 10 days by bioassay. All the antibiotic solutions except ceftazidime retained >= 90% activity at both 25 and 37°C. Thus, studies of antibiotic-heparin lock solutions with dwell times of up to 10 days are feasible.

* Corresponding author. Mailing address: Schneider Children's Hospital, 269-01 76th Ave., New Hyde Park, NY 11040. Phone: (718) 470-3480. Fax: (718) 470-0887. E-mail: lrubin{at}lij.edu.

Antimicrobial Agents and Chemotherapy, August 1999, p. 2074-2076, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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