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Antimicrobial Agents and Chemotherapy, August 1999, p. 2081-2083, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Molecular Characterization of the SHV-11 beta -Lactamase of Shigella dysenteriae

Jasimuddin Ahamed and Manikuntala Kundu*

Department of Chemistry, Bose Institute, Calcutta 700 009, India

Received 16 November 1998/Returned for modification 3 March 1999/Accepted 6 June 1999

A beta -lactamase with an Mr of 29,000 and a pI of 7.6 was partially purified from a clinical isolate of Shigella dysenteriae. The bla gene encoded the SHV-11 enzyme carrying the substitution Leuright-arrowGln at position 35 and was linked to a strong promoter. This variant, unlike the prototype SHV-1 enzyme, hydrolyzed oxacillin, cloxacillin, and oxyiminocephalosporins such as cefotaxime.

* Corresponding author. Mailing address: Department of Chemistry, Bose Institute, 93/1 Acharya Prafulla Chandra Rd., Calcutta 700 009, India. Phone: 91 33 350 6619. Fax: 91 33 3506790. E-mail: mani{at}boseinst.ernet.in.

Antimicrobial Agents and Chemotherapy, August 1999, p. 2081-2083, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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