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Antimicrobial Agents and Chemotherapy, August 1999, p. 2084-2086, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Role of Permeability in the Activities of beta -Lactams against Gram-Negative Bacteria Which Produce a Group 3 beta -Lactamase

Naoki Matsumura,1,* Shinzaburo Minami,1 Yasuo Watanabe,1 Shizuko Iyobe,2 and Susumu Mitsuhashi3

Research Laboratories, Toyama Chemical Co., Ltd., Shimookui, Toyama 930-8508,1 Laboratory of Drug Resistance in Bacteria, Gunma University School of Medicine, Maebashi Gunma 371-0034,2 and Episome Institute, Fujimi-mura, Seta-gun, Gunma 370-0103,3 Japan

Received 19 November 1998/Returned for modification 1 March 1999/Accepted 24 May 1999

The production of a group 3 beta -lactamase permitted Escherichia coli to raise the MICs of ceftazidime, cefpirome, and meropenem greatly but those of imipenem and piperacillin only slightly. The ratios of maximum rate of hydrolysis to Km of ceftazidime, cefpirome, and piperacillin were lower than those of meropenem and imipenem for the group 3 beta -lactamase. The permeability coefficients for piperacillin and meropenem were higher than those for ceftazidime and cefpirome. Imipenem had the highest permeability coefficient.

* Corresponding author. Mailing address: Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama 930-8508, Japan. Phone: 81-764-31-8268. Fax: 81-764-31-8208.

Antimicrobial Agents and Chemotherapy, August 1999, p. 2084-2086, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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