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Antimicrobial Agents and Chemotherapy, August 1999, p. 2093-2096, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

In Vitro Activities of Polycationic Peptides Alone and in Combination with Clinically Used Antimicrobial Agents against Rhodococcus equi

A. Giacometti,* O. Cirioni, F. Ancarani, M. S. Del Prete, M. Fortuna, and G. Scalise

Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy

Received 30 November 1998/Returned for modification 2 March 1999/Accepted 19 May 1999

The in vitro activities of magainin II, nisin, and ranalexin alone and in combination with other antimicrobial agents against six clinical isolates of Rhodococcus equi were investigated by MIC and time-kill studies. All isolates were more susceptible to nisin. A positive interaction was observed when the peptides were combined with ampicillin, ceftriaxone, rifabutin, rifampin, azithromycin, clarithromycin, and vancomycin.

* Corresponding author. Mailing address: Institute of Infectious Diseases and Public Health, c/o Azienda Ospedaliera Umberto I, Piazza Cappelli, 1, I-60121 Ancona, Italy. Phone: 39-071-5963467. Fax: 39-071-5963468. E-mail: cmalinf{at}popcsi.unian.it.

Antimicrobial Agents and Chemotherapy, August 1999, p. 2093-2096, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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  • Jacks, S. S., Giguere, S., Nguyen, A. (2003). In Vitro Susceptibilities of Rhodococcus equi and Other Common Equine Pathogens to Azithromycin, Clarithromycin, and 20 Other Antimicrobials. Antimicrob. Agents Chemother. 47: 1742-1745 [Abstract] [Full Text]  
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