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Antimicrobial Agents and Chemotherapy, September 1999, p. 2273-2277, Vol. 43, No. 9
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Inhibition of Escherichia coli-Induced Meningitis by Carboxyfullerence

Nina Tsao,1 Puthuparampil P. Kanakamma,2 Tien-Yau Luh,2 Chen-Kung Chou,3 and Huan-Yao Lei1,*

Department of Microbiology & Immunology, College of Medicine, National Cheng Kung University, Tainan,1 and Department of Chemistry, National Taiwan University,2 and Department of Medical Research, Veteran General Hospital,3 Taipei, Taiwan

Received 13 January 1999/Returned for modification 26 May 1999/Accepted 10 June 1999

The effect of a water-soluble malonic acid derivative of carboxyfullerence (C60) against Escherichia coli-induced meningitis was tested. C60 can protect the mice from E. coli-induced death in a dose-dependent manner. C60 administered intraperitoneally as late as 9 h after E. coli injection was still protective. The C60-treated mice had less tumor necrosis factor alpha and interleukin-1beta production by staining of brain tissue compared to the levels of production for nontreated mice. The E. coli-induced increases in blood-brain barrier permeability and inflammatory neutrophilic infiltration were also inhibited. These data suggest that C60 is a potentially therapeutic agent for bacterial meningitis.

* Corresponding author. Mailing address: Department of Microbiology & Immunology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan, Republic of China. Phone: 886-6-2353535, ext. 5643. Fax: 886-6-2082705. E-mail: hylei{at}mail.ncku.edu.tw.

Antimicrobial Agents and Chemotherapy, September 1999, p. 2273-2277, Vol. 43, No. 9
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Tsao, N., Luh, T.-Y., Chou, C.-K., Chang, T.-Y., Wu, J.-J., Liu, C.-C., Lei, H.-Y. (2002). In vitro action of carboxyfullerene. J Antimicrob Chemother 49: 641-649 [Abstract] [Full Text]  
  • TSAO, N., HSU, H.P., WU, C.M., LIU, C.C., LEI, H.Y. (2001). Tumour necrosis factor-{alpha} causes an increase in blood-brain barrier permeability during sepsis. J Med Microbiol 50: 812-821 [Abstract] [Full Text]  
  • Tsao, N., Luh, T.-Y., Chou, C.-K., Wu, J.-J., Lin, Y.-S., Lei, H.-Y. (2001). Inhibition of Group A Streptococcus Infection by Carboxyfullerene. Antimicrob. Agents Chemother. 45: 1788-1793 [Abstract] [Full Text]  


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