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Antimicrobial Agents and Chemotherapy, September 1999, p. 2328-2331, Vol. 43, No. 9
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

In Vitro Activities of Strychnos Alkaloids and Extracts against Plasmodium falciparum

Michel Frederich,1,2,* Marie-Pierre Hayette,2 Monique Tits,1 Patrick De Mol,2 and Luc Angenot1

Laboratoire de Pharmacognosie, Institut de Pharmacie, CHU du Sart Tilman, Tour 4, B36,1 and Laboratoire de Microbiologie Médicale, Institut de Pathologie, CHU du Sart Tilman, Tour 3, B23,2 Liege, Belgium

Received 11 January 1999/Returned for modification 28 May 1999/Accepted 12 July 1999

The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities against Plasmodium. Strychnopentamine and isostrychnopentamine were active against chloroquine-sensitive and -resistant strains (50% inhibitory concentration [IC50] approx  0.15 µM), while dihydrousambarensine exhibited a 30-fold higher activity against the chloroquine-resistant strain (IC50 = 0.03 µM) than it did against the chloroquine-sensitive strain.

* Corresponding author. Mailing address: Laboratoire de Pharmacognosie, Institut de Pharmacie, Avenue de l'Hôpital 1, CHU - Sart Tilman, Tour 4, B36, 4000 Liège, Belgium. Phone: 32 4 366 43 38. Fax: 32 4 366 43 32. E-mail: M.Frederich{at}ulg.ac.be.

Antimicrobial Agents and Chemotherapy, September 1999, p. 2328-2331, Vol. 43, No. 9
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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