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Antimicrobial Agents and Chemotherapy, January 2000, p. 178-180, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Trovafloxacin Concentrations in Airway Fluids of Patients with Severe Community-Acquired Pneumonia

R. A. Peleman,1,2,* V. Van De Velde,2 P. R. Germonpré,2 C. Fleurinck,2 M. T. Rosseel,3 and R. A. Pauwels2

Division of Infectious Diseases, Department of Internal Medicine,1 Department of Respiratory Diseases,2 and Heymans Institute of Pharmacology,3 University Hospital Ghent, 185 De Pintelaan, B9000 Ghent, Belgium

Received 22 March 1999/Returned for modification 24 July 1999/Accepted 19 September 1999

The penetration of trovafloxacin (TVA), 200 mg once daily, into the airways of 17 patients with severe pneumonia was studied. The mean (standard deviations are given in parentheses) steady-state TVA concentrations, 2 h after the last intake, were 3.1 (0.3) mg/liter in induced sputum (n = 8), 3.2 (1.1) mg/liter in bronchial secretions (n = 9), 3.2 (0.9) mg/liter in bronchoalveolar lavage fluid (n = 10), and 4.9 (1.4) mg/liter in epithelial lining fluid (n = 11).

* Corresponding author. Mailing address: Dept. of Respiratory Diseases, University Hospital 7K12, 185 De Pintelaan, B9000 Ghent, Belgium. Phone: 32 9 240 2147. Fax: 32 9 240 2341. E-mail: renaat.peleman{at}rug.ac.be.

Antimicrobial Agents and Chemotherapy, January 2000, p. 178-180, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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