This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tanaka, M.
Right arrow Articles by Naito, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tanaka, M.
Right arrow Articles by Naito, S.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 2000, p. 192-195, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Susceptibilities of Neisseria gonorrhoeae Isolates Containing Amino Acid Substitutions in GyrA, with or without Substitutions in ParC, to Newer Fluoroquinolones and Other Antibiotics

Masatoshi Tanaka,1,* Hiroshi Nakayama,2 Masashi Haraoka,1 Takeshi Saika,3 Intetsu Kobayashi,3 and Seiji Naito1

Department of Urology, Faculty of Medicine, Kyushu University,1 and Nakayama Urologic Clinic,2 Fukuoka, and Chemotherapy Division, Mitsubishi-kagaku BCL, Tokyo,3 Japan

Received 18 March 1999/Returned for modification 10 September 1999/Accepted 25 October 1999

We examined the antimicrobial susceptibilities of 85 Neisseria gonorrhoeae isolates, classified according to the presence of amino acid substitutions in the GyrA and ParC proteins, to 12 fluoroquinolones and 7 other antibiotics. Sitafloxacin and HSR-903 showed excellent activity against N. gonorrhoeae, including strains with both GyrA and ParC substitutions. Among the strains with various GyrA substitutions, strains with a serine-91-to-phenylalanine mutation required the highest MICs of all of the fluoroquinolones tested and were cross-resistant to structurally unrelated beta -lactams.

* Corresponding author. Mailing address: Department of Urology, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Phone: 81-92-642-5603. Fax: 81-92-642-5618. E-mail: masatosh{at}uro.med.kyushu-u.ac.jp.

Antimicrobial Agents and Chemotherapy, January 2000, p. 192-195, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Wu, H. M., Harcourt, B. H., Hatcher, C. P., Wei, S. C., Novak, R. T., Wang, X., Juni, B. A., Glennen, A., Boxrud, D. J., Rainbow, J., Schmink, S., Mair, R. D., Theodore, M. J., Sander, M. A., Miller, T. K., Kruger, K., Cohn, A. C., Clark, T. A., Messonnier, N. E., Mayer, L. W., Lynfield, R. (2009). Emergence of Ciprofloxacin-Resistant Neisseria meningitidis in North America. NEJM 360: 886-892 [Abstract] [Full Text]  
  • Dal Conte, I., Starnino, S., Di Perri, G., Stefanelli, P. (2006). Disseminated Gonococcal Infection in an Immunocompetent Patient Caused by an Imported Neisseria gonorrhoeae Multidrug-Resistant Strain.. J. Clin. Microbiol. 44: 3833-3834 [Abstract] [Full Text]  
  • Shultz, T. R., White, P. A., Tapsall, J. W. (2005). In Vitro Assessment of the Further Potential for Development of Fluoroquinolone Resistance in Neisseria meningitidis. Antimicrob. Agents Chemother. 49: 1753-1760 [Abstract] [Full Text]  
  • Kam, K. M., Kam, S. S. Y., Cheung, D. T. L., Tung, V. W. N., Au, W. F., Cheung, M. M. (2003). Molecular Characterization of Quinolone-Resistant Neisseria gonorrhoeae in Hong Kong. Antimicrob. Agents Chemother. 47: 436-439 [Abstract] [Full Text]  
  • Chaudhry, U, Ray, K, Bala, M, Saluja, D (2002). Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India. Sex. Transm. Infect. 78: 440-444 [Abstract] [Full Text]  
  • Friedman, S. M., Lu, T., Drlica, K. (2001). Mutation in the DNA Gyrase A Gene of Escherichia coli That Expands the Quinolone Resistance-Determining Region. Antimicrob. Agents Chemother. 45: 2378-2380 [Abstract] [Full Text]  
  • Shultz, T. R., Tapsall, J. W., White, P. A. (2001). Correlation of In Vitro Susceptibilities to Newer Quinolones of Naturally Occurring Quinolone-Resistant Neisseria gonorrhoeae Strains with Changes in GyrA and ParC. Antimicrob. Agents Chemother. 45: 734-738 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»