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Antimicrobial Agents and Chemotherapy, January 2000, p. 196-199, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Sequence Analysis of ARI-1, a Novel OXA beta -Lactamase, Responsible for Imipenem Resistance in Acinetobacter baumannii 6B92

Helen M. Donald,1 Wendy Scaife,1 Sebastian G. B. Amyes,2 and Hilary-Kay Young1,*

Department of Biological Sciences, University of Dundee, Dundee DD1 4HN,1 and Department of Medical Microbiology, University of Edinburgh Medical School, Edinburgh EH8 9AG,2 United Kingdom

Received 12 May 1999/Returned for modification 12 August 1999/Accepted 15 October 1999

The sequence of the blaARI-1 gene from imipenem-resistant Acinetobacter baumannii 6B92 has been determined. The structural gene encodes a 273-amino-acid protein which is most related to the OXA class D beta -lactamases. The conserved S-T-F-K and K-T-G motifs were identified in the ARI-1 protein sequence, also named OXA-23, but significantly, a point mutation (Yright-arrowF) was identified in the Y-G-N conserved motif, also known to function in the active site.

* Corresponding author. Mailing address: Department of Biological Sciences, University of Dundee, Dundee DD1 4HN, United Kingdom. Phone: 44 (0)1382 344270. Fax: 44 (0)1382 344275. E-mail: h.k.young{at}dundee.ac.uk.

Antimicrobial Agents and Chemotherapy, January 2000, p. 196-199, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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