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Antimicrobial Agents and Chemotherapy, January 2000, p. 222-225, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

A Novel Integron in Salmonella enterica Serovar Enteritidis, Carrying the blaDHA-1 Gene and Its Regulator Gene ampR, Originated from Morganella morganii

Charlotte Verdet,1,* Guillaume Arlet,1 Guilene Barnaud,2 Philippe H. Lagrange,3 and Alain Philippon4

Service de Bactériologie, Hôpital Tenon,1 Service de Bactériologie, Hôpital Lariboisière,2 Service de Microbiologie, Hôpital St. Louis,3 and Service de Bactériologie, Hôpital Cochin,4 Paris, France

Received 23 February 1999/Returned for modification 31 May 1999/Accepted 9 October 1999

The genetic organization of the gene coding for DHA-1 and the corresponding ampR gene was determined by PCR mapping. These genes have been mobilized from the Morganella morganii chromosome and inserted into a complex sulI-type integron, similar to In6 and In7. However, they are not themselves mobile cassettes. This integron probably includes a specific site for recombination allowing the mobilization of diverse resistance genes, as observed for blaCMY-1 and blaMOX-1.

* Corresponding author. Mailing address: Service de Bactériologie, Hôpital Tenon, 4, rue de la Chine, 75970 Paris Cedex 20, France. Phone: (33) (1) 56 01 70 18. Fax: (33) (1) 56 01 61 08. E-mail: service.bacterio{at}tnn.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, January 2000, p. 222-225, Vol. 44, No. 1
0066-4804/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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