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Antimicrobial Agents and Chemotherapy, October 2000, p. 2865-2868, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Efficacy of Voriconazole in a Guinea Pig Model of Disseminated Invasive Aspergillosis

William R. Kirkpatrick,1,* Robert K. McAtee,1 Annette W. Fothergill,2 Michael G. Rinaldi,2,3 and Thomas F. Patterson1,3

Departments of Medicine1 and Pathology,2 The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, and Audie Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 782843

Received 21 December 1999/Returned for modification 29 April 2000/Accepted 10 July 2000

Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericin B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.

* Corresponding author. Mailing address: The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, Mail Code 7881, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900. Phone: (210) 567-4823. Fax: (210) 567-3303. E-mail: KIRKPATRICK{at}UTHSCSA.EDU.

Antimicrobial Agents and Chemotherapy, October 2000, p. 2865-2868, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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