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Antimicrobial Agents and Chemotherapy, October 2000, p. 2887-2890, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Pharmacodynamic Characteristics of Nystatin Including Time-Kill and Postantifungal Effect

Shana M. Gunderson,1 Holly Hoffman,1 Erika J. Ernst,1 Michael A. Pfaller,2 and Michael E. Klepser1,*

College of Pharmacy1 and Department of Pathology, College of Medicine,2 The University of Iowa, Iowa City, Iowa 52242

Received 14 December 1999/Returned for modification 29 April 2000/Accepted 22 July 2000

Four Candida albicans isolates and six non-albicans Candida isolates were evaluated by time-kill methods to characterize the relationship between nystatin concentrations, the rate and extent of fungicidal activity, and the postantifungal effect (PAFE). Against Candida species, nystatin exhibits concentration-dependent fungicidal activity and a pronounced PAFE.

* Corresponding author. Mailing address: The University of Iowa College of Pharmacy, S-412 Pharmacy Bldg., Iowa City, IA 52242-1112. Phone: (319) 335-8861. Fax: (319) 353-5646. E-mail: michael-klepser{at}uiowa.edu.

Antimicrobial Agents and Chemotherapy, October 2000, p. 2887-2890, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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