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Antimicrobial Agents and Chemotherapy, October 2000, p. 2915-2918, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Itraconazole-Amphotericin B Antagonism in Aspergillus fumigatus: an E-Test-Based Strategy

Dimitrios P. Kontoyiannis,1,* Russell E. Lewis,1,2 Namita Sagar,1 Gregory May,3 Randall A. Prince,1,2 and Kenneth V. I. Rolston1

Section of Infectious Diseases, Department of Internal Medicine Specialties,1 and Division of Pathology,3 The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, and The University of Houston College of Pharmacy, Houston, Texas 772042

Received 15 May 2000/Returned for modification 6 June 2000/Accepted 12 July 2000

We examined an E-test-based strategy for testing the combination of itraconazole and amphotericin B, the latter given either sequentially or concomitantly, in isolates of Aspergillus fumigatus. An antagonistic interaction between the two drugs was noted, especially with the sequential administration of amphotericin B. This in vitro antagonism was reversible.

* Corresponding author. Mailing address: Department of Internal Medicine Specialties, Box 47, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030. Phone: (713) 792-6237. Fax: (713) 794-4351. E-mail: dkontoyi{at}notes.mdacc.tmc.edu.

Antimicrobial Agents and Chemotherapy, October 2000, p. 2915-2918, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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