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Antimicrobial Agents and Chemotherapy, November 2000, p. 3174-3176, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Postantibiotic Leukocyte Enhancement of Meropenem against Gram-Positive and Gram-Negative Strains

Andrea Novelli,* Stefania Fallani, Maria Iris Cassetta, Silvia Conti, and Teresita Mazzei

Dipartimento di Farmacologia Preclinica e Clinica, Università degli Studi di Firenze, Florence, Italy

Received 15 November 1999/Returned for modification 16 May 2000/Accepted 8 August 2000

The postantibiotic leukocyte enhancement (PALE) of meropenem in vitro in comparison with that of imipenem was evaluated with 24 recently isolated gram-positive and gram-negative strains. In general, pre-exposure to carbapenems (at four times the MIC for 2 h) led to increased polymorphonuclear cell phagocytic killing. The PALE of imipenem was generally significantly less than that observed with meropenem.

* Corresponding author. Mailing address: Dipartimento di Farmacologia Preclinica e Clinica, Università degli Studi, Viale Pieraccini, 6-50139 Firenze, Italy. Phone: 39-55-4271, ext. 310. Fax: 39-55-4271, ext. 280. E-mail: novelli{at}server1.pharm.unifi.it.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3174-3176, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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