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Antimicrobial Agents and Chemotherapy, November 2000, p. 3186-3188, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Susceptibilities of Capnocytophaga Isolates to beta -Lactam Antibiotics and beta -Lactamase Inhibitors

Anne Jolivet-Gougeon,1,* Anne Buffet,1 Cécile Dupuy,1 Jean-Louis Sixou,2 Martine Bonnaure-Mallet,2 Sandrine David,1 and Michel Cormier1

Laboratoire de Microbiologie Pharmaceutique, UPRES-EA 1254,1 and Equipe de Biologie Buccale, UPRES-EA 1256, UFR Odontologie,2 Université de Rennes I, 35000 Rennes, France

Received 21 December 1999/Returned for modification 2 May 2000/Accepted 11 August 2000

The susceptibilities of 43 pharyngeal isolates of Capnocytophaga to beta-lactam antibiotics, alone or in combination with beta-lactamase inhibitors, were tested by an agar dilution method. The 34 beta-lactamase-positive strains were highly resistant to beta-lactams, but the intrinsic activities of clavulanate, tazobactam, and sulbactam against Capnocytophaga, even beta-lactamase producers, indicates that these beta-lactamase inhibitors could be used for empirical treatment of neutropenic patients with oral sources of infection.

* Corresponding author. Mailing address: Laboratoire de Microbiologie Pharmaceutique, Université de Rennes I, 2, avenue du Professeur Léon Bernard, 35000 Rennes, France. Phone: (33) 02 99 33 69 16. Fax: (33) 02 99 33 62 60.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3186-3188, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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