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Antimicrobial Agents and Chemotherapy, November 2000, p. 3189-3192, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Impact of Flavophospholipol and Vancomycin on Conjugational Transfer of Vancomycin Resistance Plasmids

Sabine Riedl,1 Knut Ohlsen,1,* Guido Werner,2 Wolfgang Witte,2 and Jörg Hacker1

Institute for Molecular Biology of Infectious Diseases, The University of Würzburg, D-97070 Würzburg,1 and Robert-Koch-Institute, Wernigerode Branch, 38850 Wernigerode,2 Germany

Received 2 May 2000/Returned for modification 13 June 2000/Accepted 11 August 2000

The influence of vancomycin and flavophospholipol (FPL) on the transfer rate of conjugative plasmids harboring the vancomycin resistance operon vanA was determined in several clinical and animal isolates of Enterococcus faecium. FPL significantly inhibited the frequency of transfer of conjugative VanA plasmids up to 70-fold. Vancomycin had no significant effect on the transfer rate of VanA plasmids.

* Corresponding author. Mailing address: Institut für Molekulare Infektionsbiologie, Röntgenring 11, D-97070 Würzburg, Germany. Phone: 49-931-312635. Fax: 49-931-312578. E-mail: knut.ohlsen{at}mail.uni-wuerzburg.de.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3189-3192, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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