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Antimicrobial Agents and Chemotherapy, November 2000, p. 3224-3228, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Genetic Characterization of vanG, a Novel Vancomycin Resistance Locus of Enterococcus faecalis

Stuart J. McKessar,1 Anne M. Berry,1 Jan M. Bell,2 John D. Turnidge,2 and James C. Paton1,*

Molecular Microbiology Unit1 and Department of Infectious Diseases,2 Women's and Children's Hospital, North Adelaide, South Australia 5006, Australia

Received 20 March 2000/Returned for modification 9 June 2000/Accepted 21 August 2000

Enterococcus faecalis strain WCH9 displays a moderate level of resistance to vancomycin (MIC = 16 µg/ml) and full susceptibility to teicoplanin but is negative by PCR analysis using primers specific for all known enterococcal vancomycin resistance genotypes (vanA, vanB, vanC, vanD, and vanE). We have isolated and sequenced a novel putative vancomycin resistance locus (designated vanG), which contains seven open reading frames, from this strain. These are organized differently from those of all the other enterococcal van loci, and, furthermore, the individual vanG gene products exhibit less than 50% amino acid sequence identity to other van gene products.

* Corresponding author. Mailing address: Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, S.A. 5006, Australia. Phone: 61-8-8204 6302. Fax: 61-8-8204 6051. E-mail: patonj{at}wch.sa.gov.au.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3224-3228, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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