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Antimicrobial Agents and Chemotherapy, December 2000, p. 3473-3475, Vol. 44, No. 12
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Short-Term Exposure to Membrane-Active Antibiotics Inhibits Cryptosporidium parvum Infection in Cell Culture

Andrea Giacometti,* Oscar Cirioni, Maria Simona Del Prete, Francesco Barchiesi, and Giorgio Scalise

Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy

Received 2 May 2000/Returned for modification 27 June 2000/Accepted 25 September 2000

A cell culture system and double fluorogenic staining were used to study the susceptibility of Cryptosporidium parvum to membrane-active antibiotics. Buforin II and magainin II exerted a cytotoxic effect on sporozoites but did not consistently affect oocyst viability. Lasalocid and nigericin demonstrated less activity against sporozoites but reduced the infectivity of oocysts.

* Corresponding author. Mailing address: Clinica Malattie Infettive, c/o Azienda Ospedaliera Umberto I, Piazza Cappelli, 1, I-60121 Ancona, Italy. Phone: 39-071-596-3467. Fax: 39-071-596-3468. E-mail: cmalinf{at}popcsi.unian.it.

Antimicrobial Agents and Chemotherapy, December 2000, p. 3473-3475, Vol. 44, No. 12
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Guerrero, E., Saugar, J. M., Matsuzaki, K., Rivas, L. (2004). Role of Positional Hydrophobicity in the Leishmanicidal Activity of Magainin 2. Antimicrob. Agents Chemother. 48: 2980-2986 [Abstract] [Full Text]  


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