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Antimicrobial Agents and Chemotherapy, February 2000, p. 393-395, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Acquisition of Chloramphenicol Resistance by the Linearization and Integration of the Entire Staphylococcal Plasmid pC194 into the Chromosome of Streptococcus pneumoniae

Carol A. Widdowson, Peter V. Adrian, and Keith P. Klugman*

Medical Research Council, South African Institute for Medical Research, WITS Pneumococcal Diseases Research Unit, Johannesburg, South Africa

Received 17 May 1999/Returned for modification 22 July 1999/Accepted 1 November 1999

Chloramphenicol resistance in Streptococcus pneumoniae was associated with cat, which has 100% identity with catpC194 from Staphylococcus aureus. Inverse PCR with primers specific for pC194 confirmed that in some isolates the entire staphylococcal plasmid was present in the S. pneumoniae chromosome, with linearization having occurred between catpC194 and the origin of replication.

* Corresponding author. Mailing address: Pneumococcal Diseases Research Unit, SAIMR, P.O. Box 1038, Johannesburg 2000, South Africa. Phone: 27 11 489 9010. Fax: 27 11 489 9012. E-mail: keithk{at}mail.saimr.wits.ac.za.

Antimicrobial Agents and Chemotherapy, February 2000, p. 393-395, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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