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Antimicrobial Agents and Chemotherapy, February 2000, p. 411-413, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

The Macrolide-Lincosamide-Streptogramin B Resistance Determinant from Clostridium difficile 630 Contains Two erm(B) Genes

Kylie A. Farrow, Dena Lyras, and Julian I. Rood*

Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia

Received 26 April 1999/Returned for modification 4 May 1999/Accepted 29 October 1999

The ErmB macrolide-lincosamide-streptogramin B (MLS) resistance determinant from Clostridium difficile 630 contains two copies of an erm(B) gene, separated by a 1.34-kb direct repeat also found in an Erm(B) determinant from Clostridium perfringens. In addition, both erm(B) genes are flanked by variants of the direct repeat sequence. This genetic arrangement is novel for an ErmB MLS resistance determinant.

* Corresponding author. Mailing address: Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia. Phone: 61-3-9905-4825. Fax: 61-3-9905-4811. E-mail: Julian.Rood{at}med.monash.edu.au.

Antimicrobial Agents and Chemotherapy, February 2000, p. 411-413, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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