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Antimicrobial Agents and Chemotherapy, February 2000, p. 433-436, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Mechanisms of Resistance to Quinupristin-Dalfopristin among Isolates of Enterococcus faecium from Animals, Raw Meat, and Hospital Patients in Western Europe

Mehnam Soltani,1,2 David Beighton,2 John Philpott-Howard,3 and Neil Woodford1,*

Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT,1 The Guys, King's and St. Thomas' School of Dentistry, London SE5 9RW,2 and Public Health Laboratory and Medical Microbiology Department, The Guys, King's and St. Thomas' School of Medicine, London SE5 9PJ,3 United Kingdom

Received 21 June 1999/Returned for modification 17 August 1999/Accepted 16 November 1999

Twenty-eight quinupristin-dalfopristin-resistant isolates of Enterococcus faecium from hospital patients and nonhuman sources in European countries were studied. High-level resistance (MICs, >= 32 µg/ml) was associated with the presence of vat(E) (satG) (14 isolates [50%]) or vat(D) (satA) (6 isolates [21%]). These genes were not detected in eight (29%) isolates with lower levels of quinupristin-dalfopristin resistance (MICs, 4 to 16 µg/ml). This suggests the presence of further mechanisms of resistance to quinupristin-dalfopristin in E. faecium.

* Corresponding author. Mailing address: ARMRL, CPHL, 61 Colindale Ave., London NW9 5HT, United Kingdom. Phone: 44-208-200-4400. Fax: 44-208-200-7449. E-mail: nwoodford{at}phls.nhs.uk.

Antimicrobial Agents and Chemotherapy, February 2000, p. 433-436, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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