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Antimicrobial Agents and Chemotherapy, February 2000, p. 444-446, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Molecular Characterization of the beta -Lactamases from Clinical Isolates of Moraxella (Branhamella) catarrhalis Obtained from 24 U.S. Medical Centers during 1994-1995 and 1997-1998

Sandra S. Richter, Patricia L. Winokur, Angela B. Brueggemann, Holly K. Huynh, Paul R. Rhomberg, Elizabeth M. Wingert, and Gary V. Doern*

Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa

Received 21 June 1999/Returned for modification 4 October 1999/Accepted 25 October 1999

The beta -lactamases from 403 Moraxella (Branhamella) catarrhalis clinical isolates obtained during 1994-1995 and 1997-1998 U.S. multicenter surveillance studies were characterized by isoelectric focusing. The overall prevalences of the BRO-1 and BRO-2 enzymes among beta -lactamase-positive isolates were estimated to be 97.5 and 2.5%, respectively. The minimum inhibitory concentrations (MICs) of ampicillin for all BRO-2-producing isolates were <= 1 µg/ml; however, numerous beta -lactamase-positive isolates for which the ampicillin MICs were <= 1 µg/ml produced the BRO-1 enzyme (88.1%).

* Corresponding author. Mailing address: Department of Pathology, Clinical Microbiology, University of Iowa College of Medicine, Iowa City, IA 52242. Phone: (319) 356-8616. Fax: (319) 356-4916. E-mail: gary-doern{at}uiowa.edu.

Antimicrobial Agents and Chemotherapy, February 2000, p. 444-446, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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