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Antimicrobial Agents and Chemotherapy, February 2000, p. 450-452, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Failure of Short-Course Ceftriaxone Chemotherapy for Multidrug-Resistant Typhoid Fever in Children: a Randomized Controlled Trial in Pakistan

Zulfiqar A. Bhutta,* Iqtidar A. Khan, and Mamoon Shadmani

Department of Paediatrics, The Aga Khan University, Karachi, Pakistan

Received 1 February 1999/Returned for modification 31 July 1999/Accepted 5 November 1999

The precise duration of therapy of multidrug-resistant (MDR) typhoid with broad-spectrum cephalosporins is uncertain. We prospectively randomized 57 children with culture-proven MDR typhoid to receive treatment with intravenous ceftriaxone (CRO) (65 mg/kg of body weight/day) for 7 days (short course; n = 29) or 14 days (conventional; n = 28). The response to therapy, as evaluated by the serial monitoring of the typhoid morbidity score and bacteriological clearance, was comparable between groups. In contrast to the conventional therapy, 14% of the children receiving CRO for 7 days had a confirmed bacteriological relapse within 4 weeks of stopping therapy.

* Corresponding author. Mailing address: Department of Paediatrics, The Aga Khan University Medical Center, Karachi, Pakistan. Phone: 92-21-4930051, ext. 4721. Fax: 92-21-4934294 and 92-21-4932095. E-mail: zulfiqar.bhutta{at}aku.edu.

Antimicrobial Agents and Chemotherapy, February 2000, p. 450-452, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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