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Antimicrobial Agents and Chemotherapy, March 2000, p. 705-709, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

The Biopesticide Paenibacillus popilliae Has a Vancomycin Resistance Gene Cluster Homologous to the Enterococcal VanA Vancomycin Resistance Gene Cluster

Robin Patel,1,* Kerryl Piper,1 Franklin R. Cockerill III,1,2 James M. Steckelberg,1 and Allan A. Yousten3

Division of Infectious Diseases and Infectious Diseases Research Laboratory,1 and Division of Clinical Microbiology,2 Mayo Clinic and Foundation, Rochester, Minnesota, and Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia3

Received 10 June 1999/Returned for modification 13 October 1999/Accepted 22 December 1999

We have previously identified, in Paenibacillus popilliae, a 708-bp sequence which has homology to the sequence of the enterococcal vanA gene. We have performed further studies revealing five genes encoding homologues of VanY, VanZ, VanH, VanA, and VanX in P. popilliae. The predicted amino acid sequences are similar to those in VanA vancomycin-resistant enterococci: 61% identity for VanY, 21% for VanZ, 74% for VanH, 77% for VanA, and 79% for VanX. The genes in P. popilliae may have been a precursor to or have had ancestral genes in common with vancomycin resistance genes in enterococci. The use of P. popilliae biopesticidal preparations in agricultural practice may have an impact on bacterial resistance in human pathogens.

* Corresponding author. Mailing address: Division of Infectious Diseases and Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55902. Phone: (507) 255-6482. Fax: (507) 255-7767. E-mail: patel.robin{at}mayo.edu.

Antimicrobial Agents and Chemotherapy, March 2000, p. 705-709, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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