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Antimicrobial Agents and Chemotherapy, March 2000, p. 763-766, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Iron-Chelating Activity of Tetracyclines and Its Impact on the Susceptibility of Actinobacillus actinomycetemcomitans to These Antibiotics

Daniel Grenier,1,* Marie-Pierre Huot,1 and Denis Mayrand2

Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire,1 and Faculté des Sciences et de Génie,2 Université Laval, Québec, Canada

Received 24 June 1999/Returned for modification 1 October 1999/Accepted 30 November 1999

Three tetracyclines (tetracycline, doxycycline, and minocycline) were found to possess iron-chelating activity in a colorimetric siderophore assay. Determination of MICs indicated that the activity of doxycycline against the periodontopathogen Actinobacillus actinomycetemcomitans was only slightly influenced by the presence of an excess of iron that likely saturates the antibiotic. On the other hand, the MICs of doxycycline and minocycline were significantly lower for A. actinomycetemcomitans cultivated under iron-poor conditions than under iron-rich conditions.

* Corresponding author. Mailing address: Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Cité Universitaire, Québec, Canada G1K 7P4. Phone: (418) 656-7341. Fax: (418) 656-2861. E-mail: Daniel.Grenier{at}greb.ulaval.ca.

Antimicrobial Agents and Chemotherapy, March 2000, p. 763-766, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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